Faculty Profile


Santanu Bose

Santanu Bose

Professor

Caroline Engel Distinguished Professor (2015-2017)


santanu.bose@wsu.edu
Phone: 509-335-9413 Phone: 509-335-7642

 

Education & Training

BS (Biology/chemistry): Mount Olive College, North Carolina
Ph.D. (Biochemistry): Medical College of Wisconsin, Wisconsin
Post-doctoral (Virology): Cleveland Clinic, Ohio

About

Dr. Bose is currently a faculty member in the Washington State University College of Veterinary Medicine. Before moving to Washington State in 2014, Dr. Bose was a faculty member of the Department of Microbiology and Immunology in the University of Texas Health Science Center Medical School. His research is focused on understanding innate immune response against respiratory viruses like influenza A virus, human respiratory syncytial virus, parainfluenza viruses, and more recently coronaviruses, including SARS-CoV-2 (COVID-19). Particularly he is interested in elucidating the mechanisms regulating innate antiviral and inflammatory response, which play a critical role in host defense against respiratory viruses and development of hyper-inflammatory airway diseases like pneumonia. These studies are also geared to development of viral therapeutics to control virus-associated airway diseases like pneumonia.

Mechanisms regulating inflammation during respiratory virus infection
Chronic and acute inflammation is involved in pathogenesis of various inflammatory diseases like arthritis, cancer, atherosclerosis, septicemia, diabetes. Inflammation is also responsible for causing severe lung diseases like pneumonia and bronchiolitis following infection with respiratory viruses including influenza A virus (flu), human respiratory syncytial virus (RSV), parainfluenza viruses and COVID-19 causing coronavirus SARS-CoV-2. In that regard, by utilizing cellular and mice models we are studying the cellular and molecular mechanisms regulating inflammation during flu, RSV, parainfluenza virus and coronavirus (SARS-CoV-2) infection. Knowledge derived from such studies are important for uncovering the basic mechanisms that regulate inflammatory response during disease states and for development of host-based therapeutics to combat airway inflammatory disease like pneumonia. The goal is to develop broad-spectrum host-based therapeutics that can be utilized to combat cross-species deadly pandemic strains of flu and coronavirus infections.

Cellular defense mechanism during respiratory virus infection: role of antiviral innate immunity
We are studying the innate immune antiviral response against respiratory viruses including flu, RSV, parainfluenza virus and coronavirus (SARS-CoV-2). Our study focuses on dissecting the host defense mechanism that is involved in launching an innate response constituting of induction of antiviral pathways in the immune cells like macrophages, lung epithelial cells and respiratory tract. In summary, our laboratory encompasses several aspects of cellular and molecular biology/virology with emphasis on -

  1. Innate immune antiviral signal transduction pathway,
  2. Cellular and molecular mechanism that triggers and regulate inflammation, and
  3. Respiratory virus-host/cell interaction.
Select Publications
  • Bose S, Kar N, Maitra R, DiDonato JA, Banerjee AK (2003) Temporal activation of NF-kappaB regulates an interferon-independent innate antiviral response against cytoplasmic RNA viruses. Proc. Natl. Acad. Sci. USA. 100(19):10890-5. Epub 2003 Sep 5. PMID: 12960395 PMCID: PMC196898
  • Kota S, Sabbah A, Chang T. H, Harnack R, Xiang Y, Meng Y, Bose S (2008) Role of human beta-defensin-2 during tumor necrosis factor-alpha/NF-kappa B mediated innate anti-viral response against human respiratory syncytial virus. J. Biol. Chem. 283: 22417-22429 PMID: 18567888 PMCID: PMC2504899
  • Josephine Thinwa, Jesus A Segovia, Santanu Bose, Peter H Dube (2014) Integrin-mediated First Signal for Inflammasome Activation in Intestinal Epithelial Cells J Immunol. 193(3):1373-82. doi: 10.4049/jimmunol.1400145. Epub 2014 Jun 25. PMID: 24965773 PMCID: PMC4174679
  • Mgbemena V, Segovia J, Chang T, Tsai S-Y, Cole G. T, Hung C-Y, Bose S (2012) Transactivation of inducible nitric oxide synthase gene by Krüppel-like factor 6 regulates apoptosis during influenza A virus infections. J. Immunol. 189:606-615 PMID: 22711891 PMCID: PMC3392426
  • Pokharel SM, Shil NK, Gc JB, Colburn ZT, Tsai SY, Segovia JA, Chang TH, Bandyopadhyay S, Natesan S, Jones JCR, Bose S (2019) Integrin activation by the lipid molecule 25-hydroxycholesterol induces a proinflammatory response. Nature. Commun. v10(1):1482. doi: 10.1038/s41467-019-09453-x. PMID: 30931941 PMCID: PMC6443809
  • Segovia JA, Tsai S, Chang T, Shil NK, Weintraub ST, Short JD, Bose S (2015) Nedd8 regulates inflammasome-dependent caspase-1 activation. Mol. Cell. Biol. 35:582-597 PMID: 25452302 PMCID: PMC4285429
  • Bose S, Segovia J, Somarajan SE, Chang T, Kannan TR, Baseman JB (2014) ADP-ribosylation of NLRP3 by Mycoplasma pneumoniae CARDS toxin regulates inflammasome activity. MBio. 5: pii: e02186-14 PMID: 25538194 PMCID: PMC4278538
  • Tsai S, Segovia JA, Chang T, Shil NK, Pokharel SM, Kannan TR, Baseman JB, Defrene J, Pagé N, Cesaro A, Tessier PA, Bose S. (2015) Regulation of TLR3 activation by S100A9. J. Immunol. 195:4426-4437. PMID: 26385519 PMCID: PMC4747058
  • Sabbah A, Chang T, Harnack R, Frohlich V, Dube PH, Tominaga K, Xiang Y, Bose S (2009) Activation of innate immune antiviral response by Nod2. Nature. Immunol. 10(10):1073-80. doi: 10.1038/ni.1782. Epub 2009 Aug 23. PMID: 19701189 PMCID: PMC2752345
  • Shil NK, Pokharel SM, Banerjee AK, Hoffman M, Bose S (2018) Inflammasome Antagonism by Human Parainfluenza Virus Type 3 C Protein. J Virol. ;92(4). pii: e01776-17. doi: 10.1128/JVI.01776-17. Print 2018 Feb 15. PMID: 29187536 PMCID: PMC5790947
  • Tsai S, Segovia J, Mgbemena V, Chang T, Berton MT, Morris I, Tardiff M, Tessier P, Cesaro A, Bose S (2014) DAMP Molecule S100A9 Acts as a Molecular Pattern to Enhance Inflammation during Influenza A Virus Infection: Role of DDX21-TRIF-TLR4-MyD88 Pathway. PLoS. Pathogens. 10(1): e1003848 PMID: 24391503 PMCID: PMC3879357