Research Areas

Antimicrobial resistance

Santanu Bose

Professor

santanu.bose@wsu.edu

Phone: 509-335-9413 Phone: 509-335-7642

Santanu Bose

 

Education & Training

BS (Biology/chemistry): Mount Olive College, North Carolina
Ph.D. (Biochemistry): Medical College of Wisconsin, Wisconsin
Post-doctoral (Virology): Cleveland Clinic, Ohio

About

Dr. Bose is currently a faculty member in the Washington State University College of Veterinary Medicine. Before moving to Washington State in 2014, Dr. Bose was a faculty member of the Department of Microbiology and Immunology in the University of Texas Health Science Center Medical School. His research is focused on understanding innate immune response against respiratory viruses like influenza A virus, human respiratory syncytial virus, parainfluenza viruses, and more recently coronaviruses, including SARS-CoV-2 (COVID-19). Particularly he is interested in elucidating the mechanisms regulating innate antiviral and inflammatory response, which play a critical role in host defense against respiratory viruses and development of hyper-inflammatory airway diseases like pneumonia. These studies are also geared to development of viral therapeutics to control virus-associated airway diseases like pneumonia.

Select Publications
  • Bose S, Kar N, Maitra R, DiDonato JA, Banerjee AK (2003) Temporal activation of NF-kappaB regulates an interferon-independent innate antiviral response against cytoplasmic RNA viruses. Proc. Natl. Acad. Sci. USA. 100(19):10890-5. Epub 2003 Sep 5. PMID: 12960395 PMCID: PMC196898 Article
  • Kota S, Sabbah A, Chang T. H, Harnack R, Xiang Y, Meng Y, Bose S (2008) Role of human beta-defensin-2 during tumor necrosis factor-alpha/NF-kappa B mediated innate anti-viral response against human respiratory syncytial virus. J. Biol. Chem. 283: 22417-22429 PMID: 18567888 PMCID: PMC2504899 Article
  • Josephine Thinwa, Jesus A Segovia, Santanu Bose, Peter H Dube (2014) Integrin-mediated First Signal for Inflammasome Activation in Intestinal Epithelial Cells J Immunol. 193(3):1373-82. doi: 10.4049/jimmunol.1400145. Epub 2014 Jun 25. PMID: 24965773 PMCID: PMC4174679 Article
  • Mgbemena V, Segovia J, Chang T, Tsai S-Y, Cole G. T, Hung C-Y, Bose S (2012) Transactivation of inducible nitric oxide synthase gene by Krüppel-like factor 6 regulates apoptosis during influenza A virus infections. J. Immunol. 189:606-615 PMID: 22711891 PMCID: PMC3392426 Article
  • Pokharel SM, Shil NK, Gc JB, Colburn ZT, Tsai SY, Segovia JA, Chang TH, Bandyopadhyay S, Natesan S, Jones JCR, Bose S (2019) Integrin activation by the lipid molecule 25-hydroxycholesterol induces a proinflammatory response. Nature. Commun. v10(1):1482. doi: 10.1038/s41467-019-09453-x. PMID: 30931941 PMCID: PMC6443809 Article
  • Segovia JA, Tsai S, Chang T, Shil NK, Weintraub ST, Short JD, Bose S (2015) Nedd8 regulates inflammasome-dependent caspase-1 activation. Mol. Cell. Biol. 35:582-597 PMID: 25452302 PMCID: PMC4285429 Article
  • Bose S, Segovia J, Somarajan SE, Chang T, Kannan TR, Baseman JB (2014) ADP-ribosylation of NLRP3 by Mycoplasma pneumoniae CARDS toxin regulates inflammasome activity. MBio. 5: pii: e02186-14 PMID: 25538194 PMCID: PMC4278538 Article
  • Tsai S, Segovia JA, Chang T, Shil NK, Pokharel SM, Kannan TR, Baseman JB, Defrene J, Pagé N, Cesaro A, Tessier PA, Bose S. (2015) Regulation of TLR3 activation by S100A9. J. Immunol. 195:4426-4437. PMID: 26385519 PMCID: PMC4747058 Article
  • Sabbah A, Chang T, Harnack R, Frohlich V, Dube PH, Tominaga K, Xiang Y, Bose S (2009) Activation of innate immune antiviral response by Nod2. Nature. Immunol. 10(10):1073-80. doi: 10.1038/ni.1782. Epub 2009 Aug 23. PMID: 19701189 PMCID: PMC2752345 Article
  • Shil NK, Pokharel SM, Banerjee AK, Hoffman M, Bose S (2018) Inflammasome Antagonism by Human Parainfluenza Virus Type 3 C Protein. J Virol. ;92(4). pii: e01776-17. doi: 10.1128/JVI.01776-17. Print 2018 Feb 15. PMID: 29187536 PMCID: PMC5790947 Article
  • Tsai S, Segovia J, Mgbemena V, Chang T, Berton MT, Morris I, Tardiff M, Tessier P, Cesaro A, Bose S (2014) DAMP Molecule S100A9 Acts as a Molecular Pattern to Enhance Inflammation during Influenza A Virus Infection: Role of DDX21-TRIF-TLR4-MyD88 Pathway. PLoS. Pathogens. 10(1): e1003848 PMID: 24391503 PMCID: PMC3879357 Article

 


Epidemiology of infectious disease

Santanu Bose

Professor

santanu.bose@wsu.edu

Phone: 509-335-9413 Phone: 509-335-7642

Santanu Bose

 

Education & Training

BS (Biology/chemistry): Mount Olive College, North Carolina
Ph.D. (Biochemistry): Medical College of Wisconsin, Wisconsin
Post-doctoral (Virology): Cleveland Clinic, Ohio

About

Dr. Bose is currently a faculty member in the Washington State University College of Veterinary Medicine. Before moving to Washington State in 2014, Dr. Bose was a faculty member of the Department of Microbiology and Immunology in the University of Texas Health Science Center Medical School. His research is focused on understanding innate immune response against respiratory viruses like influenza A virus, human respiratory syncytial virus, parainfluenza viruses, and more recently coronaviruses, including SARS-CoV-2 (COVID-19). Particularly he is interested in elucidating the mechanisms regulating innate antiviral and inflammatory response, which play a critical role in host defense against respiratory viruses and development of hyper-inflammatory airway diseases like pneumonia. These studies are also geared to development of viral therapeutics to control virus-associated airway diseases like pneumonia.

Select Publications
  • Bose S, Kar N, Maitra R, DiDonato JA, Banerjee AK (2003) Temporal activation of NF-kappaB regulates an interferon-independent innate antiviral response against cytoplasmic RNA viruses. Proc. Natl. Acad. Sci. USA. 100(19):10890-5. Epub 2003 Sep 5. PMID: 12960395 PMCID: PMC196898 Article
  • Kota S, Sabbah A, Chang T. H, Harnack R, Xiang Y, Meng Y, Bose S (2008) Role of human beta-defensin-2 during tumor necrosis factor-alpha/NF-kappa B mediated innate anti-viral response against human respiratory syncytial virus. J. Biol. Chem. 283: 22417-22429 PMID: 18567888 PMCID: PMC2504899 Article
  • Josephine Thinwa, Jesus A Segovia, Santanu Bose, Peter H Dube (2014) Integrin-mediated First Signal for Inflammasome Activation in Intestinal Epithelial Cells J Immunol. 193(3):1373-82. doi: 10.4049/jimmunol.1400145. Epub 2014 Jun 25. PMID: 24965773 PMCID: PMC4174679 Article
  • Mgbemena V, Segovia J, Chang T, Tsai S-Y, Cole G. T, Hung C-Y, Bose S (2012) Transactivation of inducible nitric oxide synthase gene by Krüppel-like factor 6 regulates apoptosis during influenza A virus infections. J. Immunol. 189:606-615 PMID: 22711891 PMCID: PMC3392426 Article
  • Pokharel SM, Shil NK, Gc JB, Colburn ZT, Tsai SY, Segovia JA, Chang TH, Bandyopadhyay S, Natesan S, Jones JCR, Bose S (2019) Integrin activation by the lipid molecule 25-hydroxycholesterol induces a proinflammatory response. Nature. Commun. v10(1):1482. doi: 10.1038/s41467-019-09453-x. PMID: 30931941 PMCID: PMC6443809 Article
  • Segovia JA, Tsai S, Chang T, Shil NK, Weintraub ST, Short JD, Bose S (2015) Nedd8 regulates inflammasome-dependent caspase-1 activation. Mol. Cell. Biol. 35:582-597 PMID: 25452302 PMCID: PMC4285429 Article
  • Bose S, Segovia J, Somarajan SE, Chang T, Kannan TR, Baseman JB (2014) ADP-ribosylation of NLRP3 by Mycoplasma pneumoniae CARDS toxin regulates inflammasome activity. MBio. 5: pii: e02186-14 PMID: 25538194 PMCID: PMC4278538 Article
  • Tsai S, Segovia JA, Chang T, Shil NK, Pokharel SM, Kannan TR, Baseman JB, Defrene J, Pagé N, Cesaro A, Tessier PA, Bose S. (2015) Regulation of TLR3 activation by S100A9. J. Immunol. 195:4426-4437. PMID: 26385519 PMCID: PMC4747058 Article
  • Sabbah A, Chang T, Harnack R, Frohlich V, Dube PH, Tominaga K, Xiang Y, Bose S (2009) Activation of innate immune antiviral response by Nod2. Nature. Immunol. 10(10):1073-80. doi: 10.1038/ni.1782. Epub 2009 Aug 23. PMID: 19701189 PMCID: PMC2752345 Article
  • Shil NK, Pokharel SM, Banerjee AK, Hoffman M, Bose S (2018) Inflammasome Antagonism by Human Parainfluenza Virus Type 3 C Protein. J Virol. ;92(4). pii: e01776-17. doi: 10.1128/JVI.01776-17. Print 2018 Feb 15. PMID: 29187536 PMCID: PMC5790947 Article
  • Tsai S, Segovia J, Mgbemena V, Chang T, Berton MT, Morris I, Tardiff M, Tessier P, Cesaro A, Bose S (2014) DAMP Molecule S100A9 Acts as a Molecular Pattern to Enhance Inflammation during Influenza A Virus Infection: Role of DDX21-TRIF-TLR4-MyD88 Pathway. PLoS. Pathogens. 10(1): e1003848 PMID: 24391503 PMCID: PMC3879357 Article

 


Innate immunity, immunogenetics, and vaccine development

Santanu Bose

Professor

santanu.bose@wsu.edu

Phone: 509-335-9413 Phone: 509-335-7642

Santanu Bose

 

Education & Training

BS (Biology/chemistry): Mount Olive College, North Carolina
Ph.D. (Biochemistry): Medical College of Wisconsin, Wisconsin
Post-doctoral (Virology): Cleveland Clinic, Ohio

About

Dr. Bose is currently a faculty member in the Washington State University College of Veterinary Medicine. Before moving to Washington State in 2014, Dr. Bose was a faculty member of the Department of Microbiology and Immunology in the University of Texas Health Science Center Medical School. His research is focused on understanding innate immune response against respiratory viruses like influenza A virus, human respiratory syncytial virus, parainfluenza viruses, and more recently coronaviruses, including SARS-CoV-2 (COVID-19). Particularly he is interested in elucidating the mechanisms regulating innate antiviral and inflammatory response, which play a critical role in host defense against respiratory viruses and development of hyper-inflammatory airway diseases like pneumonia. These studies are also geared to development of viral therapeutics to control virus-associated airway diseases like pneumonia.

Select Publications
  • Bose S, Kar N, Maitra R, DiDonato JA, Banerjee AK (2003) Temporal activation of NF-kappaB regulates an interferon-independent innate antiviral response against cytoplasmic RNA viruses. Proc. Natl. Acad. Sci. USA. 100(19):10890-5. Epub 2003 Sep 5. PMID: 12960395 PMCID: PMC196898 Article
  • Kota S, Sabbah A, Chang T. H, Harnack R, Xiang Y, Meng Y, Bose S (2008) Role of human beta-defensin-2 during tumor necrosis factor-alpha/NF-kappa B mediated innate anti-viral response against human respiratory syncytial virus. J. Biol. Chem. 283: 22417-22429 PMID: 18567888 PMCID: PMC2504899 Article
  • Josephine Thinwa, Jesus A Segovia, Santanu Bose, Peter H Dube (2014) Integrin-mediated First Signal for Inflammasome Activation in Intestinal Epithelial Cells J Immunol. 193(3):1373-82. doi: 10.4049/jimmunol.1400145. Epub 2014 Jun 25. PMID: 24965773 PMCID: PMC4174679 Article
  • Mgbemena V, Segovia J, Chang T, Tsai S-Y, Cole G. T, Hung C-Y, Bose S (2012) Transactivation of inducible nitric oxide synthase gene by Krüppel-like factor 6 regulates apoptosis during influenza A virus infections. J. Immunol. 189:606-615 PMID: 22711891 PMCID: PMC3392426 Article
  • Pokharel SM, Shil NK, Gc JB, Colburn ZT, Tsai SY, Segovia JA, Chang TH, Bandyopadhyay S, Natesan S, Jones JCR, Bose S (2019) Integrin activation by the lipid molecule 25-hydroxycholesterol induces a proinflammatory response. Nature. Commun. v10(1):1482. doi: 10.1038/s41467-019-09453-x. PMID: 30931941 PMCID: PMC6443809 Article
  • Segovia JA, Tsai S, Chang T, Shil NK, Weintraub ST, Short JD, Bose S (2015) Nedd8 regulates inflammasome-dependent caspase-1 activation. Mol. Cell. Biol. 35:582-597 PMID: 25452302 PMCID: PMC4285429 Article
  • Bose S, Segovia J, Somarajan SE, Chang T, Kannan TR, Baseman JB (2014) ADP-ribosylation of NLRP3 by Mycoplasma pneumoniae CARDS toxin regulates inflammasome activity. MBio. 5: pii: e02186-14 PMID: 25538194 PMCID: PMC4278538 Article
  • Tsai S, Segovia JA, Chang T, Shil NK, Pokharel SM, Kannan TR, Baseman JB, Defrene J, Pagé N, Cesaro A, Tessier PA, Bose S. (2015) Regulation of TLR3 activation by S100A9. J. Immunol. 195:4426-4437. PMID: 26385519 PMCID: PMC4747058 Article
  • Sabbah A, Chang T, Harnack R, Frohlich V, Dube PH, Tominaga K, Xiang Y, Bose S (2009) Activation of innate immune antiviral response by Nod2. Nature. Immunol. 10(10):1073-80. doi: 10.1038/ni.1782. Epub 2009 Aug 23. PMID: 19701189 PMCID: PMC2752345 Article
  • Shil NK, Pokharel SM, Banerjee AK, Hoffman M, Bose S (2018) Inflammasome Antagonism by Human Parainfluenza Virus Type 3 C Protein. J Virol. ;92(4). pii: e01776-17. doi: 10.1128/JVI.01776-17. Print 2018 Feb 15. PMID: 29187536 PMCID: PMC5790947 Article
  • Tsai S, Segovia J, Mgbemena V, Chang T, Berton MT, Morris I, Tardiff M, Tessier P, Cesaro A, Bose S (2014) DAMP Molecule S100A9 Acts as a Molecular Pattern to Enhance Inflammation during Influenza A Virus Infection: Role of DDX21-TRIF-TLR4-MyD88 Pathway. PLoS. Pathogens. 10(1): e1003848 PMID: 24391503 PMCID: PMC3879357 Article

 


Parasitic, bacterial and viral zoonotic pathogens

Santanu Bose

Professor

santanu.bose@wsu.edu

Phone: 509-335-9413 Phone: 509-335-7642

Santanu Bose

 

Education & Training

BS (Biology/chemistry): Mount Olive College, North Carolina
Ph.D. (Biochemistry): Medical College of Wisconsin, Wisconsin
Post-doctoral (Virology): Cleveland Clinic, Ohio

About

Dr. Bose is currently a faculty member in the Washington State University College of Veterinary Medicine. Before moving to Washington State in 2014, Dr. Bose was a faculty member of the Department of Microbiology and Immunology in the University of Texas Health Science Center Medical School. His research is focused on understanding innate immune response against respiratory viruses like influenza A virus, human respiratory syncytial virus, parainfluenza viruses, and more recently coronaviruses, including SARS-CoV-2 (COVID-19). Particularly he is interested in elucidating the mechanisms regulating innate antiviral and inflammatory response, which play a critical role in host defense against respiratory viruses and development of hyper-inflammatory airway diseases like pneumonia. These studies are also geared to development of viral therapeutics to control virus-associated airway diseases like pneumonia.

Select Publications
  • Bose S, Kar N, Maitra R, DiDonato JA, Banerjee AK (2003) Temporal activation of NF-kappaB regulates an interferon-independent innate antiviral response against cytoplasmic RNA viruses. Proc. Natl. Acad. Sci. USA. 100(19):10890-5. Epub 2003 Sep 5. PMID: 12960395 PMCID: PMC196898 Article
  • Kota S, Sabbah A, Chang T. H, Harnack R, Xiang Y, Meng Y, Bose S (2008) Role of human beta-defensin-2 during tumor necrosis factor-alpha/NF-kappa B mediated innate anti-viral response against human respiratory syncytial virus. J. Biol. Chem. 283: 22417-22429 PMID: 18567888 PMCID: PMC2504899 Article
  • Josephine Thinwa, Jesus A Segovia, Santanu Bose, Peter H Dube (2014) Integrin-mediated First Signal for Inflammasome Activation in Intestinal Epithelial Cells J Immunol. 193(3):1373-82. doi: 10.4049/jimmunol.1400145. Epub 2014 Jun 25. PMID: 24965773 PMCID: PMC4174679 Article
  • Mgbemena V, Segovia J, Chang T, Tsai S-Y, Cole G. T, Hung C-Y, Bose S (2012) Transactivation of inducible nitric oxide synthase gene by Krüppel-like factor 6 regulates apoptosis during influenza A virus infections. J. Immunol. 189:606-615 PMID: 22711891 PMCID: PMC3392426 Article
  • Pokharel SM, Shil NK, Gc JB, Colburn ZT, Tsai SY, Segovia JA, Chang TH, Bandyopadhyay S, Natesan S, Jones JCR, Bose S (2019) Integrin activation by the lipid molecule 25-hydroxycholesterol induces a proinflammatory response. Nature. Commun. v10(1):1482. doi: 10.1038/s41467-019-09453-x. PMID: 30931941 PMCID: PMC6443809 Article
  • Segovia JA, Tsai S, Chang T, Shil NK, Weintraub ST, Short JD, Bose S (2015) Nedd8 regulates inflammasome-dependent caspase-1 activation. Mol. Cell. Biol. 35:582-597 PMID: 25452302 PMCID: PMC4285429 Article
  • Bose S, Segovia J, Somarajan SE, Chang T, Kannan TR, Baseman JB (2014) ADP-ribosylation of NLRP3 by Mycoplasma pneumoniae CARDS toxin regulates inflammasome activity. MBio. 5: pii: e02186-14 PMID: 25538194 PMCID: PMC4278538 Article
  • Tsai S, Segovia JA, Chang T, Shil NK, Pokharel SM, Kannan TR, Baseman JB, Defrene J, Pagé N, Cesaro A, Tessier PA, Bose S. (2015) Regulation of TLR3 activation by S100A9. J. Immunol. 195:4426-4437. PMID: 26385519 PMCID: PMC4747058 Article
  • Sabbah A, Chang T, Harnack R, Frohlich V, Dube PH, Tominaga K, Xiang Y, Bose S (2009) Activation of innate immune antiviral response by Nod2. Nature. Immunol. 10(10):1073-80. doi: 10.1038/ni.1782. Epub 2009 Aug 23. PMID: 19701189 PMCID: PMC2752345 Article
  • Shil NK, Pokharel SM, Banerjee AK, Hoffman M, Bose S (2018) Inflammasome Antagonism by Human Parainfluenza Virus Type 3 C Protein. J Virol. ;92(4). pii: e01776-17. doi: 10.1128/JVI.01776-17. Print 2018 Feb 15. PMID: 29187536 PMCID: PMC5790947 Article
  • Tsai S, Segovia J, Mgbemena V, Chang T, Berton MT, Morris I, Tardiff M, Tessier P, Cesaro A, Bose S (2014) DAMP Molecule S100A9 Acts as a Molecular Pattern to Enhance Inflammation during Influenza A Virus Infection: Role of DDX21-TRIF-TLR4-MyD88 Pathway. PLoS. Pathogens. 10(1): e1003848 PMID: 24391503 PMCID: PMC3879357 Article

 


Vector-borne diseases

Santanu Bose

Professor

santanu.bose@wsu.edu

Phone: 509-335-9413 Phone: 509-335-7642

Santanu Bose

 

Education & Training

BS (Biology/chemistry): Mount Olive College, North Carolina
Ph.D. (Biochemistry): Medical College of Wisconsin, Wisconsin
Post-doctoral (Virology): Cleveland Clinic, Ohio

About

Dr. Bose is currently a faculty member in the Washington State University College of Veterinary Medicine. Before moving to Washington State in 2014, Dr. Bose was a faculty member of the Department of Microbiology and Immunology in the University of Texas Health Science Center Medical School. His research is focused on understanding innate immune response against respiratory viruses like influenza A virus, human respiratory syncytial virus, parainfluenza viruses, and more recently coronaviruses, including SARS-CoV-2 (COVID-19). Particularly he is interested in elucidating the mechanisms regulating innate antiviral and inflammatory response, which play a critical role in host defense against respiratory viruses and development of hyper-inflammatory airway diseases like pneumonia. These studies are also geared to development of viral therapeutics to control virus-associated airway diseases like pneumonia.

Select Publications
  • Bose S, Kar N, Maitra R, DiDonato JA, Banerjee AK (2003) Temporal activation of NF-kappaB regulates an interferon-independent innate antiviral response against cytoplasmic RNA viruses. Proc. Natl. Acad. Sci. USA. 100(19):10890-5. Epub 2003 Sep 5. PMID: 12960395 PMCID: PMC196898 Article
  • Kota S, Sabbah A, Chang T. H, Harnack R, Xiang Y, Meng Y, Bose S (2008) Role of human beta-defensin-2 during tumor necrosis factor-alpha/NF-kappa B mediated innate anti-viral response against human respiratory syncytial virus. J. Biol. Chem. 283: 22417-22429 PMID: 18567888 PMCID: PMC2504899 Article
  • Josephine Thinwa, Jesus A Segovia, Santanu Bose, Peter H Dube (2014) Integrin-mediated First Signal for Inflammasome Activation in Intestinal Epithelial Cells J Immunol. 193(3):1373-82. doi: 10.4049/jimmunol.1400145. Epub 2014 Jun 25. PMID: 24965773 PMCID: PMC4174679 Article
  • Mgbemena V, Segovia J, Chang T, Tsai S-Y, Cole G. T, Hung C-Y, Bose S (2012) Transactivation of inducible nitric oxide synthase gene by Krüppel-like factor 6 regulates apoptosis during influenza A virus infections. J. Immunol. 189:606-615 PMID: 22711891 PMCID: PMC3392426 Article
  • Pokharel SM, Shil NK, Gc JB, Colburn ZT, Tsai SY, Segovia JA, Chang TH, Bandyopadhyay S, Natesan S, Jones JCR, Bose S (2019) Integrin activation by the lipid molecule 25-hydroxycholesterol induces a proinflammatory response. Nature. Commun. v10(1):1482. doi: 10.1038/s41467-019-09453-x. PMID: 30931941 PMCID: PMC6443809 Article
  • Segovia JA, Tsai S, Chang T, Shil NK, Weintraub ST, Short JD, Bose S (2015) Nedd8 regulates inflammasome-dependent caspase-1 activation. Mol. Cell. Biol. 35:582-597 PMID: 25452302 PMCID: PMC4285429 Article
  • Bose S, Segovia J, Somarajan SE, Chang T, Kannan TR, Baseman JB (2014) ADP-ribosylation of NLRP3 by Mycoplasma pneumoniae CARDS toxin regulates inflammasome activity. MBio. 5: pii: e02186-14 PMID: 25538194 PMCID: PMC4278538 Article
  • Tsai S, Segovia JA, Chang T, Shil NK, Pokharel SM, Kannan TR, Baseman JB, Defrene J, Pagé N, Cesaro A, Tessier PA, Bose S. (2015) Regulation of TLR3 activation by S100A9. J. Immunol. 195:4426-4437. PMID: 26385519 PMCID: PMC4747058 Article
  • Sabbah A, Chang T, Harnack R, Frohlich V, Dube PH, Tominaga K, Xiang Y, Bose S (2009) Activation of innate immune antiviral response by Nod2. Nature. Immunol. 10(10):1073-80. doi: 10.1038/ni.1782. Epub 2009 Aug 23. PMID: 19701189 PMCID: PMC2752345 Article
  • Shil NK, Pokharel SM, Banerjee AK, Hoffman M, Bose S (2018) Inflammasome Antagonism by Human Parainfluenza Virus Type 3 C Protein. J Virol. ;92(4). pii: e01776-17. doi: 10.1128/JVI.01776-17. Print 2018 Feb 15. PMID: 29187536 PMCID: PMC5790947 Article
  • Tsai S, Segovia J, Mgbemena V, Chang T, Berton MT, Morris I, Tardiff M, Tessier P, Cesaro A, Bose S (2014) DAMP Molecule S100A9 Acts as a Molecular Pattern to Enhance Inflammation during Influenza A Virus Infection: Role of DDX21-TRIF-TLR4-MyD88 Pathway. PLoS. Pathogens. 10(1): e1003848 PMID: 24391503 PMCID: PMC3879357 Article

 


Virology

Santanu Bose

Professor

santanu.bose@wsu.edu

Phone: 509-335-9413 Phone: 509-335-7642

Santanu Bose

 

Education & Training

BS (Biology/chemistry): Mount Olive College, North Carolina
Ph.D. (Biochemistry): Medical College of Wisconsin, Wisconsin
Post-doctoral (Virology): Cleveland Clinic, Ohio

About

Dr. Bose is currently a faculty member in the Washington State University College of Veterinary Medicine. Before moving to Washington State in 2014, Dr. Bose was a faculty member of the Department of Microbiology and Immunology in the University of Texas Health Science Center Medical School. His research is focused on understanding innate immune response against respiratory viruses like influenza A virus, human respiratory syncytial virus, parainfluenza viruses, and more recently coronaviruses, including SARS-CoV-2 (COVID-19). Particularly he is interested in elucidating the mechanisms regulating innate antiviral and inflammatory response, which play a critical role in host defense against respiratory viruses and development of hyper-inflammatory airway diseases like pneumonia. These studies are also geared to development of viral therapeutics to control virus-associated airway diseases like pneumonia.

Select Publications
  • Bose S, Kar N, Maitra R, DiDonato JA, Banerjee AK (2003) Temporal activation of NF-kappaB regulates an interferon-independent innate antiviral response against cytoplasmic RNA viruses. Proc. Natl. Acad. Sci. USA. 100(19):10890-5. Epub 2003 Sep 5. PMID: 12960395 PMCID: PMC196898 Article
  • Kota S, Sabbah A, Chang T. H, Harnack R, Xiang Y, Meng Y, Bose S (2008) Role of human beta-defensin-2 during tumor necrosis factor-alpha/NF-kappa B mediated innate anti-viral response against human respiratory syncytial virus. J. Biol. Chem. 283: 22417-22429 PMID: 18567888 PMCID: PMC2504899 Article
  • Josephine Thinwa, Jesus A Segovia, Santanu Bose, Peter H Dube (2014) Integrin-mediated First Signal for Inflammasome Activation in Intestinal Epithelial Cells J Immunol. 193(3):1373-82. doi: 10.4049/jimmunol.1400145. Epub 2014 Jun 25. PMID: 24965773 PMCID: PMC4174679 Article
  • Mgbemena V, Segovia J, Chang T, Tsai S-Y, Cole G. T, Hung C-Y, Bose S (2012) Transactivation of inducible nitric oxide synthase gene by Krüppel-like factor 6 regulates apoptosis during influenza A virus infections. J. Immunol. 189:606-615 PMID: 22711891 PMCID: PMC3392426 Article
  • Pokharel SM, Shil NK, Gc JB, Colburn ZT, Tsai SY, Segovia JA, Chang TH, Bandyopadhyay S, Natesan S, Jones JCR, Bose S (2019) Integrin activation by the lipid molecule 25-hydroxycholesterol induces a proinflammatory response. Nature. Commun. v10(1):1482. doi: 10.1038/s41467-019-09453-x. PMID: 30931941 PMCID: PMC6443809 Article
  • Segovia JA, Tsai S, Chang T, Shil NK, Weintraub ST, Short JD, Bose S (2015) Nedd8 regulates inflammasome-dependent caspase-1 activation. Mol. Cell. Biol. 35:582-597 PMID: 25452302 PMCID: PMC4285429 Article
  • Bose S, Segovia J, Somarajan SE, Chang T, Kannan TR, Baseman JB (2014) ADP-ribosylation of NLRP3 by Mycoplasma pneumoniae CARDS toxin regulates inflammasome activity. MBio. 5: pii: e02186-14 PMID: 25538194 PMCID: PMC4278538 Article
  • Tsai S, Segovia JA, Chang T, Shil NK, Pokharel SM, Kannan TR, Baseman JB, Defrene J, Pagé N, Cesaro A, Tessier PA, Bose S. (2015) Regulation of TLR3 activation by S100A9. J. Immunol. 195:4426-4437. PMID: 26385519 PMCID: PMC4747058 Article
  • Sabbah A, Chang T, Harnack R, Frohlich V, Dube PH, Tominaga K, Xiang Y, Bose S (2009) Activation of innate immune antiviral response by Nod2. Nature. Immunol. 10(10):1073-80. doi: 10.1038/ni.1782. Epub 2009 Aug 23. PMID: 19701189 PMCID: PMC2752345 Article
  • Shil NK, Pokharel SM, Banerjee AK, Hoffman M, Bose S (2018) Inflammasome Antagonism by Human Parainfluenza Virus Type 3 C Protein. J Virol. ;92(4). pii: e01776-17. doi: 10.1128/JVI.01776-17. Print 2018 Feb 15. PMID: 29187536 PMCID: PMC5790947 Article
  • Tsai S, Segovia J, Mgbemena V, Chang T, Berton MT, Morris I, Tardiff M, Tessier P, Cesaro A, Bose S (2014) DAMP Molecule S100A9 Acts as a Molecular Pattern to Enhance Inflammation during Influenza A Virus Infection: Role of DDX21-TRIF-TLR4-MyD88 Pathway. PLoS. Pathogens. 10(1): e1003848 PMID: 24391503 PMCID: PMC3879357 Article